The MESA Day Northern California Regional Competition is an annual event that provides MESA Students with the opportunity to apply math, science and engineering skills during individual and team competitions. This competition gives students who are consistently participating throughout their academic career an opportunity to master their skills, build confidence and motivate students to excel.

MESA Day Regional is held at a different location each year, which gives students an opportunity to explore campuses in different cities and industry locations. The 2018-2019 MESA Day Regional Competition was held in the Northern California Google headquarters.